Zoloft, Paxil, Luvox and Prozac are currently used by more than five million Americans. Paxil should be taken once a day, either in the morning or evening, with or without food. Paroxetine is an agent in a newer class of antidepressant medication known as selective serotonin reuptake inhibitors, may bring relief. With depression, the most severe cognitive and behavioral malfunctions are expressed in what is called a major depressive disorder, as stated by others.

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